The King of Pop--of the world!!!

No other musician has had a bigger impact. Nobody has ever come close. As I was making a chart of the working model of RNAi pathway and heterochromatin, a new email came in from LA Times.

Michael, I love you, your music and your dance moves. And I'm sure the whole world is with me on this.

Great help, guy from "HELP" desk!

From: Sent: Thu 6/25/2009 1:58 PM To: Lim, Su Jun Cc: Subject: RE: Unable to connect via VPN Attachments: View As Web Page

Try again. Steve -----Original Message----- From: Lim, Su Jun Sent: Thursday, June 25, 2009 2:13 AM To: Subject: Unable to connect via VPN Hi. I'm trying to connect to the URMC vpn using Cisco VPN client 4.9.01 (0080) on a mac 10.5.7. I'm able to import the VPN from the URMC website but unable to log on with my username and password, which i used for my email account. How can I fix it? Thanks. -SuJun Lim

Qualifying to be in the fraternity of SCIENCE

At the end of the day, the scientific community can be comparable to a bigger, wealthier fraternity. First, you need to get yourself behind the door. Then, you get to choose your "Big". To qualify as one of "them", you'd better start speaking the language and learning the code. After all, SCIENCE feeds on the communication of the findings among scientists (a.k.a. the fraternity members). Without communication, science is dead.

Good luck.

The Process of Crafting a Career Path

Crafting your own career path... If you have chosen "science" as your career field, good luck. And yes, good luck to me. Interest or passion helps. However, the constant stifling scientific research in the lab (where you spend most of your waking hours) may, or may not, kill however much interest or passion you have. Just a possibility, I say.

One thing I have come to realize is this limiting cap we put on ourselves. I graduated with an engineering degree; I am going to be an engineer. I graduated with a music degree; I will be a musician for my whole life, etc. etc. etc. You get the idea. This is more so for PhD graduates. I say TAKE OFF THE CAP! Quit limiting yourself from doing what you are capable of doing!

Here is an interesting article from http://sciencecareers.sciencemag.org
Special Feature: Not What You Thought You'd Be Doing

The article features Angelo Vermeulen, my hero/scientist-artist-musician-gamer, Jorge Cham, the famous PHD cartoonist, and interestingly Jeff Mangahas, who switched to a winery from a lab. Very interesting indeed.

Moral learned from the article: Don't limit yourself to what you "think" you should do.

miR-125b, a novel negative regulator of p53

miR-125b was shown to regulate p53 expression. Interestingly, the miRNA response element (MRE) located at the 3' UTR of p53 was found to be targeted among different species.

Le et al., Genes Dev 2009

Third year - still pre-qualified

At this point in my graduate career, it is time to look back and gather some useful "preliminary data".

EPIGENETICS

How does MFP (my favorite protein) holla at the RNAi machinery to give the chromatin a little makeover so that some genes get to be turned on or off? That is the question I'm attempting to answer by devoting 3+x years in the lab of my choice.